研究室業績2007-2011

2013

Characteristics of glioma stem cells (Review article).

Sampetrean O and Saya H
Brain Tumor Pathol. 2013 Apr 13. [Epub ahead of print]

Twist2 functions as a tumor suppressor in murine osteosarcoma cells.

Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H Cancer Sci. 2013 Apr 4. doi: 10.1111/cas.12163. [Epub ahead of print]

IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells.

Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H.
Stem Cells. 2012 Apr;31(4):627-40. doi: 10.1002/stem.1328.

Redox regulation in stem-like cancer cells by CD44 variant isoforms (Review article).

Nagano O, Okazaki S and Saya H
Oncogene. 2013 Jan 21. doi: 10.1038/onc.2012.638. [Epub ahead of print]

xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma.

Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O.
Cancer Res. 2013 Mar 15;73(6):1855-66. doi: 10.1158/0008-5472.CAN-12-3609-T. Epub 2013 Jan 14.

Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1α axis.

Goto TM, Arima Y, Nagano O, Saya H.
Cell Struct Funct. 2013 Jan 19;38(1):9-14. Epub 2012 Nov 30.

Complexity of cancer stem cells (Review Article).

Sugihara E, Saya H.
Int J Cancer. 2013 Mar 15;132(6):1249-59. doi: 10.1002/ijc.27961. Epub 2012 Dec 17. Review.

共同研究2007-2012

2013

APC(CDH1) Targets MgcRacGAP for Destruction in the Late M Phase.

Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T.
PLoS One. 2013 May 16;8(5):e63001. doi: 10.1371/journal.pone.0063001. Print 2013.

cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.

Kim M, Kim M, Lee S, Kuninaka S, Saya H, Lee H, Lee S, Lim DS.
EMBO J. 2013 May 3. doi: 10.1038/emboj.2013.102. [Epub ahead of print]

The Arf/p53 Protein Module, Which Induces Apoptosis, Down-regulates Histone H2AX to Allow Normal Cells to Survive in the Presence of Anti-cancer Drugs.

Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka K.
J Biol Chem. 2013 May 10;288(19):13269-77. doi: 10.1074/jbc.M112.402560. Epub 2013 Mar 27.

Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.

Kai K, Iwamoto T, Kobayashi T, Arima Y, Takamoto Y, Ohnishi N, Bartholomeusz C, Horii R, Akiyama F, Hortobagyi GN, Pusztai L, Saya H and Ueno NT
Oncogene. 2013 Feb 4. doi: 10.1038/onc.2012.609. [Epub ahead of print]

Arf and p53 act as guardians of a quiescent cellular state by protecting against immortalization of cells with stable genomes.

Osawa T, Atsumi Y, Sugihara E, Saya H, Kanno M, Tashiro F, Masutani M, Yoshioka K.
Biochem Biophys Res Commun. 2013 Mar 1;432(1):34-9. doi: 10.1016/j.bbrc.2013.01.091. Epub 2013 Jan 31.

Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta.

Kobayashi Y, Banno K, Shimizu T, Ueki A, Tsuji K, Masuda K, Kisu I, Nomura H, Tominaga E, Nagano O, Saya H, Aoki D.
Placenta. 2013 Feb;34(2):110-8. doi: 10.1016/j.placenta.2012.11.003. Epub 2012 Nov 28.