研究室業績2007-2012

2009

Molecularly targeted therapies for glioma.

Yamanaka R, Saya H.
Ann Neurol. 2009 Dec;66(6):717-29.

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model.

Kai K, Nagano O, Sugihara E, Arima Y, Sampetrean O, Ishimoto T, Nakanishi M, Ueno NT, Iwase H, Saya H.
Cancer Sci. 2009 Dec;100(12):2275-82.

Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.

Inumaru J, Nagano O, Takahashi E, Ishimoto T, Nakamura S, Suzuki Y, Niwa S, Umezawa K, Tanihara H, Saya H.
Genes Cells. 2009 Jun;14(6):703-16.

K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.

Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H, Yamashita Y.
Cancer Res. 2009 May 1;69(9):3901-9.

Reversible whole-organism cell cycle arrest in a living vertebrate.

Sampetrean O, Iida S, Makino S, Matsuzaki Y, Ohno K, Saya H.
Cell Cycle. 2009 Feb 15;8(4):620-7.

共同研究

2009

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.

Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada J, Hirao A.
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17163-8. Epub 2009 Sep 17.

Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2.

Tei S, Saitoh N, Funahara T, Iida S, Nakatsu Y, Kinoshita K, Kinoshita Y, Saya H, Nakao M. J Cell Sci. 2009 Sep 1;122(Pt 17):3190-8. Epub 2009 Aug 11.

Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, Mann DJ, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E.
J Cell Biol. 2009 Aug 10;186(3):393-407.

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.

Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T.
J Exp Med. 2009 May 11;206(5):1089-102. Epub 2009 Apr 27.

Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization.

Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K.
Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4410-5.

Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.

Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N.
Int J Cancer. 2009 Jun 1;124(11):2607-15.