研究室業績2007-2012

2010

Mad2 inhibits the mitotic kinesin MKlp2.

Lee SH, McCormick F, Saya H.
J Cell Biol. 2010 Dec 13;191(6):1069-77.

The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.

Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S.
Mol Cell Biol. 2010 Aug;30(16):3994-4005.

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis.

Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O. Cancer Sci. 2010 Mar;101(3):673-8.

Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1.

Arima Y, Hayashi H, Kamata K, Goto TM, Sasaki M, Kuramochi A, Saya H. Exp Dermatol. 2010 Aug;19(8):e136-41.

Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.

Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H.
J Biol Chem. 2010 Feb 5;285(6):4060-73. Epub 2009 Dec 4.

Breast cancer stem cells.

Kai K, Arima Y, Kamiya T, Saya H.
Breast Cancer. 2010 Apr;17(2):80-5. Epub 2009 Oct 6. (Review article)

共同研究

2010

Identification of CD44 as a cell surface marker for Müller glia precursor cells.

Shinoe T, Kuribayashi H, Saya H, Seiki M, Aburatani H, Watanabe S. J Neurochem. 2010 Dec;115(6):1633-42.

PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma.

Loilome W, Juntana S, Namwat N, Bhudhisawasdi V, Puapairoj A, Sripa B, Miwa M, Saya H, Riggins GJ, Yongvanit P.
Int J Cancer. 2011 Jul 1;129(1):34-44.

Proteome profiling reveals gender differences in the composition of human serum.

Miike K, Aoki M, Yamashita R, Takegawa Y, Saya H, Miike T, Yamamura K. Proteomics. 2010 Jul;10(14):2678-91.

Experimental therapies: Investigator-initiated cancer trials with INDs for approval in Japan.

Imamura CK, Takebe N, Nakamura S, Saya H, Ueno NT.
Nat Rev Clin Oncol. 2010 Mar;7(3):127-8.

PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties.

Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N.
Cancer Res. 2010 Feb 1;70(3):1215-24. Epub 2010 Jan 26.

Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway.

Techasen A, Loilome W, Namwat N, Takahashi E, Sugihara E, Puapairoj A, Miwa M, Saya H, Yongvanit P.
Cancer Sci. 2010 Mar;101(3):658-65. Epub 2009 Nov 7.