研究室業績2007-2013

2012

Up-regulation of Imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.

Ueki A, Shimizu T, Masuda K, Yamaguchi SI, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto A, Toyama Y, Banno K, Aoki D, Saya H.
PLoS One. 2012;7(11):e50621. doi: 10.1371/journal.pone.0050621. Epub 2012 Nov 30.

Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells (Review Article).

Tamada M, Suematsu M, Saya H.
Clin Cancer Res. 2012 Oct 15;18(20):5554-61. doi: 10.1158/1078-0432.CCR-12-0859.

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T, Mogushi K, Tanaka H, Osawa T, Kanki Y, Minami T, Aburatani H, Ohmura M, Kubo A, Suematsu M, Takahashi K, Saya H, Nagano O.
Nat Commun. 2012 Jun 6;3:883. doi: 10.1038/ncomms1892.

Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer.

Arima Y, Hayashi N, Hayashi H, Sasaki M, Kai K, Sugihara E, Abe E, Yoshida A, Mikami S, Nakamura S, Saya H.
Int J Cancer. 2012 Jun 1;130(11):2568-79. doi: 10.1002/ijc.26271. Epub 2011 Aug 24.

LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.

Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihama Y, Saya H, Kuninaka S.
J Cell Biol. 2012 May 28;197(5):625-41. doi: 10.1083/jcb.201110110.

Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM,Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H.J Biol Chem. 2012Mar 9;287(11):7896-906. doi: 10.1074/jbc.M111.313759. Epub 2012 Jan 19.

Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma.

Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E,Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori H, Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y, Saya H.Mol Cancer Res. 2012 Mar;10(3):454-68. doi: 10.1158/1541-7786.MCR-11-0347. Epub 2012 Jan 6.

Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.

Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H, Kanno M, Miwa M, Okada S, Andreeff M, Saya H. Oncogene. 2012 Jun 7;31(23):2849-61. doi: 10.1038/onc.2011.462. Epub 2011 Oct 10.

共同研究2007-2013

2012

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells.

Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano O, Matsuzaki J, Hibi T.
Cell Host Microbe. 2012 Dec 13;12(6):764-77. doi: 10.1016/j.chom.2012.10.014.

In vivo assessment of cancerous tumors using boron doped diamond microelectrode.

Fierro S, Yoshikawa M, Nagano O, Yoshimi K, Saya H, Einaga Y.
Sci Rep. 2012;2:901. doi: 10.1038/srep00901. Epub 2012 Nov 29.

Reciprocal control of G1-phase progression is required for Th-POK/Runx3-mediated CD4/8 thymocyte cell fate decision.

Sato T, Chiba T, Ohno S, Sato C, Sugoh T, Miyashita K, Akatsuka H, Hozumi K, Okada Y, Iida Y, Akatsuka A, Agata Y, Chiba M, Kohu K, Satake M, Tanabe H, Saya H, Habu S.
J Immunol. 2012 Nov 1;189(9):4426-36. doi: 10.4049/jimmunol.1102748. Epub 2012 Sep 26.

Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.

Oikawa T, Oyama M, Kozuka-Hata H, Uehara S, Udagawa N, Saya H, Matsuo K. J Cell Biol. 2012 May 14;197(4):553-68. doi: 10.1083/jcb.201111116.

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma.

Mima K, Okabe H, Ishimoto T, Hayashi H, Nakagawa S, Kuroki H, Watanabe M, Beppu T, Tamada M, Nagano O, Saya H, Baba H.Cancer Res. 2012 Jul 1;72(13):3414-23. doi: 10.1158/0008-5472.CAN-12-0299. Epub 2012 May 2.

RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.

Muto J, Imai T, Ogawa D, Nishimoto Y, Okada Y, Mabuchi Y, Kawase T, Iwanami A, Mischel PS, Saya H, Yoshida K, Matsuzaki Y, Okano H.PLoS One. 2012;7(3):e33431. doi: 10.1371/journal.pone.0033431. Epub 2012 Mar 12.

Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells.

Masuko K, Okazaki S, Satoh M, Tanaka G, Ikeda T, Torii R, Ueda E, Nakano T, Danbayashi M, Tsuruoka T, Ohno Y, Yagi H, Yabe N, Yoshida H, Tahara T, Kataoka S, Oshino T, Shindo T, Niwa S, Ishimoto T, Baba H, Hashimoto Y, Saya H, Masuko T.PLoS One. 2012;7(1):e29728. doi: 10.1371/journal.pone.0029728. Epub 2012 Jan 17.

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/C(Cdh1) in Senescent Cells.

Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G,Saya H, Hara E.Mol Cell. 2012 Jan 13;45(1):123-31. doi: 10.1016/j.molcel.2011.10.018. Epub 2011 Dec 15.

Expression profiles of carcinosarcoma of the uterine corpus-are these similar to carcinoma or sarcoma?

Chiyoda T, Tsuda H, Tanaka H, Kataoka F, Nomura H, Nishimura S, Takano M, Susumu N, Saya H, Aoki D.Genes Chromosomes Cancer. 2012 Mar;51(3):229-39. doi: 10.1002/gcc.20947. Epub 2011 Nov 10.