研究室業績2007-2020

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2017

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.

Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, Ghosh S, Epstein DM, Dymock BW, Lee SH.
Nat Commun. 2017 Dec 19;8(1):2200. doi: 10.1038/s41467-017-02287-5.

スルファサラジン

佐谷 秀行, 永野 修
Medical Science Digest 2017 Nov 43巻13号 Page644-646

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

Kawano Y, Iwama E, Tsuchihashi K, Shibahara D, Harada T, Tanaka K, Nagano O, Saya H, Nakanishi Y, Okamoto I.
Lung Cancer. 2017 Nov;113:72-78. doi: 10.1016/j.lungcan.2017.09.008.

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

Shitara K, Doi T, Nagano O, Fukutani M, Hasegawa H, Nomura S, Sato A, Kuwata T, Asai K, Einaga Y, Tsuchihashi K, Suina K, Maeda Y, Saya H, Ohtsu A.
Gastric Cancer. 2017 Nov;20(6):1004-1009. doi: 10.1007/s10120-017-0720-y.

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.

Minami N, Maeda Y, Shibao S, Arima Y, Ohka F, Kondo Y, Maruyama K, Kusuhara M, Sasayama T, Kohmura E, Saya H, Sampetrean O.
Cancer Med. 2017 Nov;6(11):2635-2645. doi: 10.1002/cam4.1174.

Establishment of pten knockout medaka with transcription activator-like effector nucleases (TALENs) as a model of PTEN deficiency disease.

Matsuzaki Y, Sakuma T, Yamamoto T, Saya H.
PLoS One. 2017 Oct 20;12(10):e0186878. doi: 10.1371/journal.pone.0186878.

Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury.

Yu L, Moriguchi T, Kaneko H, Hayashi M, Hasegawa A, Nezu M, Saya H, Yamamoto M, Shimizu R.
Mol Cell Biol. 2017 Oct 27;37(22). pii: e00211-17. doi: 10.1128/MCB.00211-17.

ZEB1 expression is a potential indicator of invasive endometriosis.

Furuya M, Masuda H, Hara K, Uchida H, Sato K, Sato S, Asada H, Maruyama T, Yoshimura Y, Katabuchi H, Tanaka M, Saya H.
Acta Obstet Gynecol Scand. 2017 Sep;96(9):1128-1135. doi: 10.1111/aogs.13179.

Stat3 as a potential therapeutic target for rheumatoid arthritis.

Oike T, Sato Y, Kobayashi T, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Saya H, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
Sci Rep. 2017 Sep 8;7(1):10965. doi: 10.1038/s41598-017-11233-w.

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.

Otsubo K, Nosaki K, Imamura CK, Ogata H, Fujita A, Sakata S, Hirai F, Toyokawa G, Iwama E, Harada T, Seto T, Takenoyama M, Ozeki T, Mushiroda T, Inada M, Kishimoto J, Tsuchihashi K, Suina K, Nagano O, Saya H, Nakanishi Y, Okamoto I.
Cancer Sci. 2017 Sep;108(9):1843-1849. doi: 10.1111/cas.13309.

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.

Miyano K, Cabral H, Miura Y, Matsumoto Y, Mochida Y, Kinoh H, Iwata C, Nagano O, Saya H, Nishiyama N, Kataoka K, Yamasoba T.
J Control Release. 2017 Sep 10;261:275-286. doi: 10.1016/j.jconrel.2017.06.021.

Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.

Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H.
Cancer Sci. 2017 Sep;108(9):1793-1802. doi: 10.1111/cas.13304.

Endothelium-induced three-dimensional invasion of heterogeneous glioma initiating cells in a microfluidic coculture platform.

Chonan Y, Taki S, Sampetrean O, Saya H, Sudo R.
Integr Biol (Camb). 2017 Sep 18;9(9):762-773. doi: 10.1039/c7ib00091j.

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.

Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Lin SJ, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P.
Gastroenterology. 2017 Jul;153(1):191-204.e16. doi: 10.1053/j.gastro.2017.03.046.

Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma.

Nishino M, Ozaki M, Hegab AE, Hamamoto J, Kagawa S, Arai D, Yasuda H, Naoki K, Soejima K, Saya H, Betsuyaku T.
J Cancer. 2017 Jul 1;8(10):1774-1785. doi: 10.7150/jca.19732.

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer.

Tayama S, Motohara T, Narantuya D, Li C, Fujimoto K, Sakaguchi I, Tashiro H, Saya H, Nagano O, Katabuchi H.
Oncotarget. 2017 Jul 4;8(27):44312-44325. doi: 10.18632/oncotarget.17871.

(第6章)がん代謝と創薬 幹細胞と創薬

サンペトラ・オルテア , 佐谷 秀行
実験医学 2017 Jun 35巻Oct号 Page1725-1729

NF1ノックアウトメダカを用いた体色異常の研究

大槻 雄士, 國仲 慎治, 佐谷 秀行
日本レックリングハウゼン病学会雑誌 2017 May 8巻1号 Page52-55

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.

Kasai S, Furuichi Y, Ando N, Kagami K, Abe M, Nakane T, Goi K, Inukai T, Saitoh S, Ohno S, Okazaki S, Nagano O, Saya H, Sugita K.
Cell Death Dis. 2017 Jun 1;8(6):e2857. doi: 10.1038/cddis.2017.249.

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells.

Kikuchi R, Sampetrean O, Saya H, Yoshida K, Toda M.
J Neurooncol. 2017 Jun;133(2):297-307. doi: 10.1007/s11060-017-2457-1.

Epithelial-mesenchymal transition is predetermined by the epigenetic state of the skin tumor cell of origin.

Semba T, Arima Y
Stem Cell Investig. 2017 May 9;4:37. doi: 10.21037/sci.2017.04.04.

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma.

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S.
Free Radic Biol Med. 2017 May;106:91-99. doi: 10.1016/j.freeradbiomed.2017.02.011.

治療戦略を考えるうえでのLuminal/HER2乳癌の基礎

木村聖美、有馬好美
医学のあゆみ 2017 Apr 261巻5号 Page463-468

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.

Sato A, Mizobuchi Y, Nakajima K, Shono K, Fujihara T, Kageji T, Kitazato K, Matsuzaki K, Mure H, Kuwayama K, Sumi A, Saya H, Sampetrean O, Nagahirao S.
J Neurooncol. 2017 Apr;132(2):231-238. doi: 10.1007/s11060-017-2380-5.

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

Ishizawa J, Sugihara E, Kuninaka S, Mogushi K, Kojima K, Benton CB, Zhao R, Chachad D, Hashimoto N, Jacamo RO, Qiu Y, Yoo SY, Okamoto S, Andreeff M, Kornblau SM, Saya H.
Blood. 2017 Apr 6;129(14):1958-1968. doi: 10.1182/blood-2016-07-726216.

Dose-escalation study for the targeting of CD44v(+) cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

Shitara K, Doi T, Nagano O, Imamura CK, Ozeki T, Ishii Y, Tsuchihashi K, Takahashi S, Nakajima TE, Hironaka S, Fukutani M, Hasegawa H, Nomura S, Sato A, Einaga Y, Kuwata T, Saya H, Ohtsu A.
Gastric Cancer. 2017 Mar;20(2):341-349. doi: 10.1007/s10120-016-0610-8.

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.

Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N.
Oncogene. 2017 Mar 2;36(9):1276-1286. doi: 10.1038/onc.2016.293.

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis.

Jeong S, Choi E, Petersen CP, Roland JT, Federico A, Ippolito R, D'Armiento FP, Nardone G, Nagano O, Saya H, Romano M, Goldenring JR.
United European Gastroenterol J. 2017 Feb;5(1):37-44. doi: 10.1177/2050640616644142.

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

Yagishita A, Ueno T, Esumi H, Saya H, Kaneko K, Tsuchihara K, Urano Y.
Bioconjug Chem. 2017 Feb 15;28(2):302-306. doi: 10.1021/acs.bioconjchem.6b00618.

Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.

Kamel WA, Sugihara E, Nobusue H, Yamaguchi-Iwai S, Onishi N, Maki K, Fukuchi Y, Matsuo K, Muto A, Saya H, Shimizu T.
Mol Cancer Ther. 2017 Jan;16(1):182-192. doi: 10.1158/1535-7163.MCT-16-0499.

RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis.

Sato R, Nakano T, Hosonaga M, Sampetrean O, Harigai R, Sasaki T, Koya I, Okano H, Kudoh J, Saya H, Arima Y.
Biomed Res Int. 2017 Jan;2017:8032910. doi: 10.1155/2017/8032910.