研究室業績2007-2020

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2018

がん幹細胞を標的とした治療耐性克服戦略

佐谷 秀行, 永野 修
病理と臨床 2018 Dec 36巻12号 Page1188-1192

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling.

Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, Okazaki S, Sampetrean O, Baba E, Akashi K, Mitsuishi Y, Takahashi F, Takahashi K, Saya H, Nagano O.
Cancer Sci. 2018 Dec;109(12):3874-3882. doi: 10.1111/cas.13826.

Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression.

Miyoshi S, Tsugawa H, Matsuzaki J, Hirata K, Mori H, Saya H, Kanai T, Suzuki H.
Anticancer Res. 2018 Nov;38(11):6163-6170. doi: 10.21873/anticanres.12969.

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease.

Tabata Y, Imaizumi Y, Sugawara M, Andoh-Noda T, Banno S, Chai M, Sone T, Yamazaki K, Ito M, Tsukahara K, Saya H, Hattori N, Kohyama J, Okano H.
Stem Cell Reports. 2018 Nov 13;11(5):1171-1184. doi: 10.1016/j.stemcr.2018.09.006.

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice.

Mukai S, Ogawa Y, Saya H, Kawakami Y, Tsubota K.
PLoS One. 2018 Oct 11;13(10):e0203742. doi: 10.1371/journal.pone.0203742.

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.

Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H.
Nat Med. 2018 Oct;24(10):1579-1589. doi: 10.1038/s41591-018-0140-5.

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.

Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.
Oncotarget. 2018 Sep 18;9(73):33832-33843. doi: 10.18632/oncotarget.26112.

HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer.

Hosonaga M, Arima Y, Sampetrean O, Komura D, Koya I, Sasaki T, Sato E, Okano H, Kudoh J, Ishikawa S, Saya H, Ishikawa T.
Int J Mol Sci. 2018 Jul 24;19(8). pii: e2158. doi: 10.3390/ijms19082158.

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells.

Ouchi T, Morikawa S, Shibata S, Takahashi M, Yoshikawa M, Soma T, Miyashita H, Muraoka W, Kameyama K, Kawana H, Arima Y, Saya H, Okano H, Nakagawa T, Asoda S.
J Dent Res. 2018 Jul;97(7):779-786. doi: 10.1177/0022034518759278.

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma.

Semba T, Sugihara E, Kamoshita N, Ueno S, Fukuda K, Yoshino M, Takao K, Yoshikawa K, Izuhara K, Arima Y, Suzuki M, Saya H.
Cancer Sci. 2018 May;109(5):1447-1454. doi: 10.1111/cas.13554.

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, et al.
Nat Commun. 2018 Apr 19;9(1):1561. doi: 10.1038/s41467-018-03899-1.

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.

Harigai R, Sakai S, Nobusue H, Hirose C, Sampetrean O, Minami N, Hata Y, Kasama T, Hirose T, Takenouchi T, Kosaki K, Kishi K, Saya H, Arima Y.
Sci Rep. 2018 Apr 17;8(1):6069. doi: 10.1038/s41598-018-24484-y.

造血器腫瘍におけるMYCの役割

杉原 英志, 石澤 丈, 佐谷 秀行
実験医学 2018 Mar 36巻4号 Page494-500

Prospects for new lung cancer treatments that target EMT signaling.

Otsuki Y, Saya H, Arima Y.
Dev Dyn. 2018 Mar;247(3):462-472. doi: 10.1002/dvdy.24596.

Development of a functional thyroid model based on an organoid culture system.

Saito Y, Onishi N, Takami H, Seishima R, Inoue H, Hirata Y, Kameyama K, Tsuchihashi K, Sugihara E, Uchino S, Ito K, Kawakubo H, Takeuchi H, Kitagawa Y, Saya H, Nagano O.
Biochem Biophys Res Commun. 2018 Mar 4;497(2):783-789. doi: 10.1016/j.bbrc.2018.02.154.

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model.

Shibao S, Minami N, Koike N, Fukui N, Yoshida K, Saya H, Sampetrean O.
Neuro Oncol. 2018 Feb 19;20(3):343-354. doi: 10.1093/neuonc/nox170.

CD44 variant inhibits insulin secretion in pancreatic ホイ cells by attenuating LAT1-mediated amino acid uptake.

Kobayashi N, Okazaki S, Sampetrean O, Irie J, Itoh H, Saya H.
Sci Rep. 2018 Feb 12;8(1):2785. doi: 10.1038/s41598-018-20973-2.

日本皮膚科学会ガイドライン 神経線維腫症1型(レックリングハウゼン病)診療ガイドライン2018

吉田 雄一, 倉持 朗, 太田 有史, 古村 南夫, 今福 信一, 松尾 宗明, 筑田 博隆, 舟崎 裕記, 齋藤 清, 佐谷 秀行, 錦織 千佳子, 神経線維腫症1型診療ガイドライン改定委員会
日本皮膚科学会雑誌 2018 Jan 128巻1号 Page17-34

Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer.

Hagiwara M, Kikuchi E, Tanaka N, Kosaka T, Mikami S, Saya H, Oya M.
BMC Cancer. 2018 Jan 31;18(1):113. doi: 10.1186/s12885-018-3988-3.

Modeling phenotypes of malignant gliomas.

Sampetrean O, Saya H.
Cancer Sci. 2018 Jan;109(1):6-14. doi: 10.1111/cas.13351.

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer.

Yamauchi T, Espinosa Fernandez JR, Imamura CK, Yamauchi H, Jinno H, Takahashi M, Kitagawa Y, Nakamura S, Lim B, Krishnamurthy S, Reuben JM, Liu D, Tripathy D, Chen H, Takebe N, Saya H, Ueno NT.
Oncotarget. 2018 Jan 4;9(6):6872-6882. doi: 10.18632/oncotarget.23914.

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model.

Haryu S, Saito R, Jia W, Shoji T, Mano Y, Sato A, Kanamori M, Sonoda Y, Sampetrean O, Saya H, Tominaga T.
J Neurooncol. 2018 Jan;136(1):23-31. doi: 10.1007/s11060-017-2621-7.