研究室業績2007-2020

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2019

び漫性神経線維腫(diffuse neurofibroma)に対する外科治療

酒井 成貴, 有馬 好美, 坂本 好昭, 中島 由佳理, 佐谷 秀行, 貴志 和生
小児外科 2019 Dec 51巻12号 Page1184-1187

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma.

Sato T, Yoo S, Kong R, Sinha A, Chandramani-Shivalingappa P, Patel A, Fridrikh M, Nagano O, Masuko T, Beasley MB, Powell CA, Zhu J, Watanabe H.
Cancer Res. 2019 Dec 15;79(24):6084-6100.

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery.

Yamamoto K, Kokubun T, Sato K, Akaishi T, Shimazaki A, Nakamura M, Shiga Y, Tsuda S, Omodaka K, Saya H, Nakazawa T.
Sci Rep. 2019 Dec 17;9(1):19288. doi: 10.1038/s41598-019-55365-7.

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma.

Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O.
Cancer Sci. 2019 Nov;110(11):3453-3463. doi: 10.1111/cas.14182.

Neuroprotective effects of memantine via enhancement of autophagy.

Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N.
Biochem Biophys Res Commun. 2019 Oct 8;518(1):161-170. doi: 10.1016/j.bbrc.2019.08.025.

Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension.

Isobe S, Kataoka M, Endo J, Moriyama H, Okazaki S, Tsuchihashi K, Katsumata Y, Yamamoto T, Shirakawa K, Yoshida N, Shimoda M, Chiba T, Masuko T, Hakamata Y, Kobayashi E, Saya H, Fukuda K, Sano M.
Am J Respir Cell Mol Biol. 2019 Sep;61(3):367-379. doi: 10.1165/rcmb.2018-0231OC.

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.

Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, et al.
Nat Cell Biol. 2019 Aug;21(8):1003-1014. doi: 10.1038/s41556-019-0363-9.

がん幹細胞とメタボロミクス

サンペトラ・オルテア , 佐谷 秀行
医学のあゆみ 2019 Aug 270巻5号 Page417-423

Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial).

Morimoto S, Takahashi S, Fukushima K, Saya H, Suzuki N, Aoki M, Okano H, Nakahara J.
Regen Ther. 2019 Jul 26;11:143-166. doi: 10.1016/j.reth.2019.07.002.

ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells.

Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H.
Cancer Res. 2019 Jun 15;79(12):3088-3099. doi: 10.1158/0008-5472.CAN-18-2693.

State of the art マウスモデルを用いた胃癌幹細胞へのアプローチ

清島 亮, 永野 修, 佐谷 秀行
胃がんperspective 2019 May 10巻3号 Page200-205

Visualization of spatiotemporal dynamics of human glioma stem cell invasion.

Tamura R, Miyoshi H, Sampetrean O, Shinozaki M, Morimoto Y, Iwasawa C, Fukaya R, Mine Y, Masuda H, Maruyama T, Narita M, Saya H, Yoshida K, Okano H, Toda M.
Mol Brain. 2019 May 6;12(1):45. doi: 10.1186/s13041-019-0462-3.

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors.

Suzuki K, Miura Y, Mochida Y, Miyazaki T, Toh K, Anraku Y, Melo V, Liu X, Ishii T, Nagano O, Saya H, Cabral H, Kataoka K.
J Control Release. 2019 May 10;301:28-41. doi: 10.1016/j.jconrel.2019.02.021.

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment.

Motohara T, Masuda K, Morotti M, Zheng Y, El-Sahhar S, Chong KY, Wietek N, Alsaadi A, Karaminejadranjbar M, Hu Z, Artibani M, Gonzalez LS, Katabuchi H, Saya H, Ahmed AA.
Oncogene. 2019 Apr;38(16):2885-2898. doi: 10.1038/s41388-018-0637-x.

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer.

Ogihara K, Kikuchi E, Okazaki S, Hagiwara M, Takeda T, Matsumoto K, Kosaka T, Mikami S, Saya H, Oya M.
Cancer Sci. 2019 Apr;110(4):1431-1441. doi: 10.1111/cas.13960.

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori-Infected CAPZA1-Overexpressing Cells.

Tsugawa H, Kato C, Mori H, Matsuzaki J, Kameyama K, Saya H, Hatakeyama M, Suematsu M, Suzuki H.
Cell Mol Gastroenterol Hepatol. 2019 May;8(3):319-334. doi: 10.1016/j.jcmgh.2019.05.008.